Cas no. : 94-24-6
Molecular formula: c15h24n2o2
Molecular weight: 264.36
Einecs no. : 202-316-6
1. Tetracaine hcl is synthesized from 4-butylaminobenzoic acid. the ethyl ester is formed through an acid-catalyzed esterification reaction. base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
2. Tetracaine is the t in tac, a mixture of 5 to 12 per cent tetracaine, 5 (per myriad), a half per mille (0.5‰), or .05 per cent (1 part in 2000) adrenaline, and 4 or 10 per cent cocaine hydrochloride used in ear, nose & throat surgery and in the emergemcy department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.
3. It is on the world health organization's list of essential medicines, a list of the most important medication needed in a basic health system.a systematic review and meta-analysis of randomised controlled trials investigated tetracaine for use in emergency departments, especially for iv cannulation in children, in view of its analgesic and cost-saving properties - however it did not find a statistically significant improvement in first attempt cannulations.